| Name | Pifithrin-α, p-Nitro, Cyclic |
| Description | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53. |
| In vitro | Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1]. |
| In vivo | Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5 mg/mL (16.70 mM), Sonication is recommended.
DMF : 12.5 mg/mL (41.76 mM), Sonication is recommended.
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| Keywords | WAF1 | posttranscriptional | Pifithrin-α, p-Nitro, Cyclic | Pifithrinα, pNitro, Cyclic | Pifithrin-alpha, p-Nitro, Cyclic | Pifithrin-a, p-Nitro, Cyclic | Pifithrin α, p Nitro, Cyclic | PFN-alpha | PFN-a | p53-triggered | P53 | p21 | neurons | MDM-2/p53 | Inhibitor | inhibit | expression | death | cortical | cell |
| Inhibitors Related | USP7-IN-4 | Rotenone | XI-006 | Verbascoside | DPBQ | Roslin 2 bromide | BAY 1892005 | C16 Ceramide | Indole-3-carbinol | RITA | P53R3 | CT-1 |
| Related Compound Libraries | Ferroptosis Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Ubiquitination Compound Library | Anti-Cancer Metabolism Compound Library | Pyroptosis Compound Library | Inhibitor Library | Metabolism Compound Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
United States
