| 名称 | Pifithrin-α, p-Nitro, Cyclic |
| 描述 | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is a cell-permeable, active-form inhibitor of p53. |
| 体外活性 | Pifithrin-α, p-Nitro, Cyclic (PFN-α) significantly inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons exposed to etoposide, requiring concentrations an order of magnitude lower than PFT-α[1]. |
| 体内活性 | Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5 mg/mL (16.70 mM), Sonication is recommended.
DMF : 12.5 mg/mL (41.76 mM), Sonication is recommended.
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| 关键字 | MDM-2/p53 | Inhibitor | expression | p21 | neurons | cortical | Pifithrin-a, p-Nitro, Cyclic | WAF1 | Pifithrinα, pNitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic | inhibit | death | p53-triggered | PFN-alpha | posttranscriptional | cell | Pifithrin-alpha, p-Nitro, Cyclic | Pifithrin α, p Nitro, Cyclic | PFN-a |
| 相关产品 | MMRi64 | Rotenone | XI-006 | Pifithrin-μ | DPBQ | Roslin 2 bromide | BAY 1892005 | Indole-3-carbinol | Magnolol | RITA | P53R3 | CT-1 |
| 相关库 | 抗肺癌化合物库 | 铁死亡化合物库 | 经典已知活性库 | 抗癌细胞代谢库 | 细胞焦亡化合物库 | 抑制剂库 | 代谢化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 转录因子库 |
United States
