Name | Piclidenoson |
Description | Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients. |
Cell Research | [3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1]. |
In vitro | Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 60 mg/mL (117.58 mM), Sonication is recommended.
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Keywords | Piclidenoson | diseases | P1 receptor | inhibit | Inhibitor | leukemia | CF 101 | CF101 | Apoptosis | prostate | melanoma | antiproliferative | colon | Adenosine Receptor | inflammatory | breast | autoimmune | COVID-19 |
Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |