| Name | Phillyrin |
| Description | Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. |
| In vitro | Phillyrin suppressed high glucose-induced lipid accumulation in HepG2 cells. Phillyrin strongly inhibited high glucose-induced fatty acid synthase (FAS) expression by modulating sterol regulatory element-binding protein-1c (SREBP-1c) activation. Moreover, use of the pharmacological AMP-activated protein kinase (AMPK) inhibitor revealed that AMPK is essential for suppressing SREBP-1c expression in Phillyrin-treated cells. Liver kinase B1 (LKB1) phosphorylation is required for the Phillyrin-enhanced activation of AMPK in HepG2 hepatocytes. |
| In vivo | Phillyrin has anti-obesity effect in nutritive obesity mice. Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), the diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 91 mg/mL (170.2 mM)
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| Keywords | Cytochrome P450 | CYPs | Inhibitor | inhibit | Phillyrin | Influenza Virus |
| Inhibitors Related | Tebuconazole | α-Vitamin E | Nitazoxanide | Fenofibrate | Curcumin | Methyl cinnamate | Naringin | Metformin hydrochloride | Naringenin | Salcomine | Chitosan oligosaccharide | Crystal Violet |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Anti-infective Natural Product Library |
United States
