| Name | Pheophorbide a |
| Description | Pheophorbide A is a photosensitizer used in in vivo photodynamic therapy (PDT).Phoophorbide A is a lymphatic vasoreactivator with antioxidant, anti-inflammatory, antitumor, and hypoglycemic activities.Phoophorbide A is used in research on diabetes and cancer. |
| In vitro | Pheophorbide A significantly inhibited the growth of Hep3B cells with an IC50 value of 1.5 μM. The intracellular ROS level was increased in the cells treated with Pa-PDT, and the cytotoxic effect could be reversed when ascorbic acid was applied[2]. |
| In vivo | In male immunocompetent C3H mice ( six-week-old, inoculated subcutaneously with AT-84 cells ), Pheophorbide A ( 10 mg / kg intravenous ( i.v. ) or a 30 mg / kg intraperitoneal ( i.p. ) injection ; after 24 h) significantly inhibited tumor growth up to 70 %[1]。 |
| Storage | keep away from direct sunlight,keep away from moisture,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1 mg/mL (1.69 mM), Sonication is recommended.
DMF : 1 mg/mL (1.69 mM), Sonication is recommended.
DMSO:PBS(pH 7.2) (1:3) : 0.25 mg/mL (0.42 mM), Sonication is recommended.
Methanol : < 1 mg/mL (Insoluble)
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| Keywords | Pheophorbide a | Antioxidant |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Tributyrin | L-Methionine | Sodium citrate | Cystamine dihydrochloride | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Miao medicine Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
