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| Common Name | Phenacetin |
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| CAS Number | 62-44-2 | Molecular Weight | 179.216 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 323.6±44.0 °C at 760 mmHg |
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| Molecular Formula | C10H13NO2 | Melting Point | 133-136 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 149.5±28.4 °C |
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| Symbol |  
GHS07, GHS08 | Signal Word | Danger |
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Use of Phenacetin
Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].
Phenacetin Biological Activity
| Description | Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3]. |
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| Related Catalog | Research Areas >> Inflammation/Immunology |
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| Target | COX-3:102 μM (IC50) |
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| References | [1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. [2]. Brix, A.E., Renal papillary necrosis. Toxicol Pathol, 2002. 30(6): p. 672-4. [3]. Dubach, U.C., B. Rosner, and T. Sturmer, An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med, 1991. 324(3): p. 155-60. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|
| Boiling Point | 323.6±44.0 °C at 760 mmHg |
|---|
| Melting Point | 133-136 °C(lit.) |
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| Molecular Formula | C10H13NO2 |
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| Molecular Weight | 179.216 |
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| Flash Point | 149.5±28.4 °C |
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| Exact Mass | 179.094635 |
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| PSA | 38.33000 |
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| LogP | 2.01 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.506 |
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| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
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| Water Solubility | 0.076 g/100 mL |
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