PF-07284892 NEW

$1520.00 25mg

$1980.00 50mg

$2500.00 100mg

TargetMol Chemicals Inc.

1YR

United States

Chemical Properties

Company Profile Introduction

Name	PF-07284892
Description	PF-07284892 (ARRY-558) is an orally active, potent SHP2 inhibitor with an IC50 of 21 nM, known to reduce the expression of pERK [1] [2].
In vitro	PF-07284892 (100 nM; 4, 18 h), in combination with lorlatinib (0-450 nM) or binimetinib (0-160 nM), reduces pERK expression in H3122 lorR-06 and VACO-432 cells [2].
In vivo	PF-07284892 (10 mg/kg; p.o.) exhibited high oral bioavailability, with F% values of 85% in mice, 94% in rats, 102% in dogs, and 64% in monkeys [2].
Storage	Shipping with blue ice.