Oclacitinib Maleate (CAS 1640292-55-2)
🌟 ChemicalBook Product Profile
📌 Product Overview
Oclacitinib Maleate (C₁₉H₂₇N₅O₆S) is a selective JAK1 inhibitor with a molecular weight of 453.51 g/mol. This white crystalline powder (≥99% purity, HPLC-validated) is specifically formulated for veterinary use, effectively treating allergic dermatitis and pruritus in dogs by targeting JAK1-dependent cytokines. It minimizes off-target effects on JAK2/JAK3, ensuring safety and efficacy. Available in 1kg/5kg/25kg sealed packaging, stable for 2 years under dry, light-protected storage (-20°C recommended).
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✅ Key Advantages
🔹 High Selectivity
IC50 of 10 nM for JAK1 | 74-fold selectivity over JAK2/JAK3.
🔹 Pharmaceutical-Grade Purity
≥99% purity (HPLC/NMR validated) | Complies with EP/USP standards.
🔹 Stability Assurance
Maintains potency for 2 years under recommended storage conditions.
🏥 Application Fields
Veterinary Medicine: Core API for oral tablets targeting canine allergic dermatitis and pruritus.
Pharmaceutical R&D: Key intermediate in JAK inhibitor development and preclinical studies.
Global API Supply: Bulk production for veterinary drug manufacturers.
📜 Quality Certifications
Testing Methods: HPLC, NMR, mass spectrometry, microbial limit testing.
Certifications: GMP, ISO 9001, and ICH stability guidelines compliance.
📊 Market Trends
The global veterinary dermatology market is projected to grow at 7.5% CAGR (2025-2030), driven by rising pet ownership and demand for targeted therapies. JAK inhibitors like Oclacitinib dominate 30% of the veterinary anti-inflammatory drug segment, with Asia-Pacific as the leading API production hub.
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