Name | Pentamidine dihydrochloride |
Description | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent effective against various microorganisms, including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). It is a potent and selective inhibitor of protein tyrosine phosphatases and phosphatase of regenerating liver. Pentamidine dihydrochloride inhibits the parasite Leishmania infantum with an IC50 of 2.5 μM. |
In vitro | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
In vivo | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 4.13 mg/mL (10 mM), Sonication is recommended.
|
Keywords | PTP1B | Pneumocystis | Parasite | Antibiotic | Pentamidine | MP601205 | antitumor | Inhibitor | Kidney | carinii | Bacterial | cell-cycle | pneumonia | Phosphatase | inhibit | MP 601205 | MP-601205 | DNA | Pentamidine dihydrochloride | MP 601205 Dihydrochloride | MP601205 Dihydrochloride | Pentamidine Dihydrochloride | biosynthetics | MP-601205 Dihydrochloride | Fungal | arrest |
Inhibitors Related | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Dimethyl sulfoxide |
Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |