| Name | PD128907 HCl |
| Description | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
| In vitro | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3] |
| In vivo | PD128907 HCl is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD128907 HCl (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | Ethanol : <1 mg/mL
H2O : 46 mg/mL (160.97 mM), Sonication is recommended.
DMSO : 10 mg/mL (34.99 mM), Sonication is recommended.
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| Keywords | PD-128907 HCl | PD128907 HCl | DopamineReceptor | Dopamine Receptor | D3 receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Olanzapine | Clozapine N-Oxide | Mirtazapine | Promazine hydrochloride | Octopamine hydrochloride | Benserazide hydrochloride | Citicoline | Oxolinic acid | Mianserin hydrochloride | Fluphenazine dihydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library |
United States
