| Name | pCPA methyl ester hydrochloride |
| Description | pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability. |
| In vivo | In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or i.p. PCPA methyl ester hydrochloride(250, 500 mg/kg), respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% and 50%[4]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 45 mg/mL (179.91 mM), Sonication and heating to 60℃ are recommended. DMSO : 245 mg/mL (979.53 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.99 mM), Sonication is recommended.
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| Keywords | Tryptophan Hydroxylase | Tryptophan hydroxylase | Serotonin Receptor | reversible | pCPA methyl ester Hydrochloride | pCPA methyl ester hydrochloride | PCPA methyl ester | insomnia | Inhibitor | inhibit | BBB | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT Receptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Casein | Ketoconazole | 1,8-Cineole | Tryptamine hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Angiogenesis related Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Serotonin Receptor-Targeted Compound Library |