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ChemicalBook Product Catalog PB28 dihydrochloride

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PB28 dihydrochloride NEW

$ 86.00 /2mg

Min. Order
Purity99.97%
Cas No172907-03-8
Supply Ability10g
Update time2024-11-15

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

1YR

United States

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Chemical Properties

Product Name	PB28 dihydrochloride
CAS No	172907-03-8
EC-No
Min. Order
Purity	99.97%
Supply Ability	10g
Release date	2024/11/15

Product Introduction

Bioactivity

名称	PB28 dihydrochloride
描述	PB28 dihydrochloride is a selective and potent sigma 2 (σ2) receptor agonist and σ1 receptor antagonist with anti-SARS-CoV-2 activity and anti-tumor activity, which inhibits cell proliferation and invasion and suppresses SKF by modulating the PI3K-AKT-mTOR signaling pathway in renal cancer. It inhibits cell proliferation and invasion by regulating the PI3K-AKT-mTOR signaling pathway in renal cancer, inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells, and induces non-caspase-dependent apoptosis.
体外活性	PB28 dihydrochloride has a higher affinity for the σ2 receptor, with Ki values of 0.28 nM and 0.17 nM in MCF7 and MCF7 ADR cells, respectively.Accumulation of the two types of cells in the G0-G1 phase was observed after treatment of MCF7 and MCF7 ADR cells for 24-48 h at concentrations of 15-25 nM, an effect that was not affected by time and concentration changes. and concentration changes. After 2 days of incubation, PB28 dihydrochloride effectively inhibited the growth of MCF7 and MCF7 ADR cells with IC50s of 25 nM and 15 nM, respectively.This compound triggers apoptosis through a non-cysteoaspartase-dependent pathway. In addition, PB28 dihydrochloride significantly reduced P-gp expression in a concentration- and time-dependent manner by approximately 60% in MCF7 cells and 90% in MCF7 ADR cells. PB28 dihydrochloride also exhibited significant antiproliferative toxicity in the C6 rat glioma cell line and the SK-N-SH human neuroblastoma cell line. [1]
体内活性	PB28 dihydrochloride was injected daily intraperitoneally at a concentration of 10.7 mg/mL for two weeks into C57BL/6 female mice and was shown to be effective in inhibiting tumor growth in Panc02 tumor-loaded mice. In addition, PB28 dihydrochloride significantly increased the survival rate of mice. [2]
存储条件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 4 mg/mL (9.02 mM), Sonication is recommended. H2O : 5 mg/mL (11.27 mM), Sonication is recommended.
关键字	PB-28 \| PB28 \| PB 28
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