| 名称 | Patamostat HCl |
| 描述 | Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis. |
| 体内活性 | In rats or rabbits, Patamostat (intravenous infusion) at doses of 0.03-0.3 mg/kg or 0.3-3.0 mg/kg, respectively, reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].In dogs with pancreatitis, Patamostat (intravenous infusion) at doses of 1.0-3.0 mg/kg reduces the increases of serum trypsin and lipase activities[1].In male Wistar rats, continuous infusion of Patamostat (2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme[2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (111.38 mM)
|
| 关键字 | 114568-26-2 Free base | 114568-26-2 | Patamostat HCl |
| 相关产品 | PMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | Leupeptin Hemisulfate | Ceritinib | Aprotinin | EDTA, Disodium Salt, Dihydrate | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
| 相关库 | 经典已知活性库 | 抑制剂库 | 已知活性化合物库 |
United States
