Paliperidone NEW

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Introduction

Product Name :Paliperidone

Other name:Paliperidone (Invega);3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-;    

CAS No.: 144598-75-4

MF:C23H27FN4O3

MW:426.48

Appearance: White Powder

Melting Point :158-160°C (dec.)(lit.)

Boiling Point :612.3±65.0 °C(Predicted)

Density :1.45±0.1 g/cm3(Predicted)

Storage :Keep in dark place,Sealed in dry,Room Temperature

 Paliperidone, (±)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one(Invega), is essentially insoluble in water and is available asextended-release tablets. Paliperidone is delivered at a constantrate using an osmotic drug release device (OsmoticRelease Oral Systems [OROS]). Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential.