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ChemicalBook Product Catalog p2Ca acetate(142606-55-1 free base)

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p2Ca acetate(142606-55-1 free base) NEW

$123.00 1mg

$298.00 5mg

$443.00 10mg

Min. Order
Purity98.36%
Cas No
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

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Chemical Properties

Product Name	p2Ca acetate(142606-55-1 free base)
CAS No
EC-No
Min. Order
Purity	98.36%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	p2Ca acetate(142606-55-1 free base)
Description	p2Ca acetate is a naturally processed peptide that derives from a ubiquitous enzyme, alpha-ketoglutarate dehydrogenase, and is recognized in association with the class I MHC protein, Ld, by a CTL clone (2C).
In vitro	p2Ca and QL9 peptides assume distinct conformations when bind to Ld and, furthermore, demonstrate that there is flexibility in peptide binding within the MHC class I cleft. Ld antigenic peptide p2Ca (LSPFPFDL) is 8-mer that lack the proline at position 2 and thus use alternative amino-terminal anchors. The p2Ca octamer is identified as the ligand that is naturally processed and presented to the Ld-alloreactive T cell clone, 2C[1]. p2Ca, is immunodominant in allorecognition of the murine MHC class I molecule H-2Ld. The majority of Ld-alloreactive T-cell clones are specific for Ld-p2Ca and this immunodominance is not due to peptide cross-reactivity[2]. p2Ca is a ubiquitously expressed self-peptide. p2Ca is derived from the mouse mitochondrial enzyme α-ketoglutarate dehydrogenase. p2Ca is present in every tissue of BALB/c mice that has been examined, including the spleen and thymus. It is also expressed by mouse tumor cell lines such as the mastocytoma P815. CTL derived in vitro recognize specifically the p2Ca/L d complex and use Vβ8 regions predominantly. The cultured cells lyse target cells with lower levels of p2Ca than the levels used for induction. This result suggests that it may be possible to use peptides at high concentrations to elicit CTL that react with endogenous levels of a peptide/class I complex[3].
In vivo	BALB/c mice, coinjected with a syngeneic BALB/c myeloma and exogenous p2Ca, are able to reject the tumor. The p2Ca/L d system may thus provide a model for evaluating the parameters for effective immunotherapy with tumor-associated peptides[3].
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 10 mM
Keywords	p2Ca acetate(142606-55-1 free base) \| p-2Ca acetate(142606-55-1 free base) \| p2Ca acetate(142606 55 1 free base) \| p2Ca acetate(142606551 free base)
Related Compound Libraries	Bioactive Compound Library \| Peptide Compound Library \| Bioactive Compounds Library Max

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Company Profile Introduction

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