What Does P21 Do?
In the simplest terms, P21 boosts cognition and protects the central nervous system from
damage. It appears to do this by boosting the maturation of neurons from precursor cells
into full-fledged neurons. It also appears to boost synaptogenesis or the interconnection
between neurons, which is a fundamental component of learning and strengthening
memory.
In more specific terms, the molecule has a host of benefits on learning,memory, and
cognitive function. In mouse models, for instance, P21 enhances object discrimination
and improves spacial reasoning. It has been shown to boost levels of brain-derived
neurotrophic factor and neurotrophin-4. It has been shown in animal studies to boost
levels of synapsin 1, GluR1, and NR1, all of which are markers of neurogenesis and
synapse formation. Interestingly, it boosts levels of these proteins in disease, but boosts
them to supraphysiologic levels in health, suggesting that P21 may aid learning and
memory even in healthy brains.
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