| Name | p-Hydroxycinnamic acid |
| Description | p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. |
| In vitro | p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (6.09 mM), Sonication is recommended. DMSO : 6.25 mg/mL (38.07 mM), Sonication is recommended.
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| Keywords | Thromboxane A2 synthetase | ProstaglandinReceptor | Prostaglandin Receptor | p-Hydroxycinnamic acid | pHydroxycinnamic acid | PGE2 | p Hydroxycinnamic acid | NSC-59260 | NSC59260 | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Cysteamine hydrochloride | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |