| Name | Oxytocin |
| Description | Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering. |
| In vitro | METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were measured by Hoechst 33342 stained.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1] |
| In vivo | METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was administered to a carrageenan-induced rat foot-plantar edema model.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate at the doses of 50 mg/kg and 70 mg/kg showed significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. Tris(2,4-di-tert-butylphenyl)phosphate significantly reduced the volume of raw paw edema. [2] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (49.64 mM)
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| Keywords | Syntocinon | a-Hypophamine | alpha-Hypophamine | Oxytocin |
| Inhibitors Related | LIT-001 | Atosiban acetate | Pro8-Oxytocin TFA | PF-06478939 | SSR126768A | Pro8-Oxytocin | PF-06478939 TFA | L-371,257 | Carbetocin | Carbetocin acetate | Oxytocin acetate | (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin |
| Related Compound Libraries | Bioactive Compound Library | Cyclic Peptide Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
