Orlistat name
The Chinese name is Ollista
[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate
Chinese alias orlistat | the listed company
More English nicknames
Orlistat bioactivity
Description Orlistat is a lipase inhibitor used to control obesity that acts by inhibiting the absorption of dietary fat.
Related category
Signal path > > Metabolic enzyme/protease > > Fatty acid synthase (FAS)
Research Field > > Metabolic disease
Reference literature
[1]. Zhi J, et al. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol. 1995 Nov; 35 (11) : 1103-8.
[2]. Padwal R, et al. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004; (3):CD004094.
[3]. Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15; 10(3). pii: E353.
Physicochemical properties of orlistat
Density 1.0± 0.1g /cm3
Boiling point 615.9±30.0 °C at 760 mmHg
Melting point DHS 50 C
Molecular formula C29H53NO5
Molecular weight 495.735
Flash point 326.3±24.6 °C
Accurate mass 495.392365
PSA 81.70000
LogP 8.94
Appearance solid | white
Vapor pressure 0.0±1.8 mmHg at 25°C
Refractive index 1.470
Storage conditions 2-8°C
Water soluble DMSO: 19 mg/mL
China
