| Name | Orexin A (human, rat, mouse) (acetate) |
| Description | Orexin A (human, rat, mouse) acetate (Hypocretin-1) is an excitatory neuropeptide with analgesic properties. It activates Orexin-1 (OX1R) and Orexin-2 (OX2R) receptors, used for studying neurodegenerative diseases. |
| In vitro | Orexin A (human, rat, mouse) acetate (0.1, 1, 10, 100 nM, 24h) increased the expression of BDNF in SH-SY5Y human dopaminergic neuroblastoma cells. [1]
Orexin A (human, rat, mouse) acetate (5μM) therapy alleviated the decrease in the number of MC3T3-E1 cells and OCN expression induced by chronic intermittent hypoxia (CIH) by combining with OX1R. [2] |
| In vivo | Orexin A (human, rat, mouse) acetate(300 ng/ mouse, injected into the brain) significantly improved spatial learning and memory impairment in MPTP-induced Parkinson's disease mouse models. [1]
Orexin A (human, rat, mouse) acetate treatment improved bone formation in CIH mice. [2] |
| Storage | keep away from moisture | Shipping with blue ice. |
| Solubility Information | H2O : 40 mg/mL (11.05 mM), Sonication is recommended.
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| Inhibitors Related | L-368,899 hydrochloride | YNT-185 | IPSU | MK-3697 | Filorexant | Suntinorexton | Orexin B, rat, mouse Acetate | OXA (17-33) acetate | PF3274167 | ACT-462206 | Seltorexant | TCS 1102 |