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ChemicalBook Product Catalog Opicapone

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Opicapone NEW

$59.00 1mg

$143.00 5mg

$243.00 10mg

Min. Order
Purity99.36%
Cas No923287-50-7
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Opicapone
CAS No	923287-50-7
EC-No
Min. Order
Purity	99.36%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Opicapone
Description	Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations.
In vitro	Opicapone decreases the mitochondrial membrane potential of the cells (IC50: 181 μM). Opicapone has a prolonged inhibitory effect on peripheral COMT, which extends the bioavailability of L-DOPA, without inducing toxicity. Incubation of human primary hepatocytes for 24 h with increasing concentrations of Ro 40-7592, OR-611 or Opicapone resulted in a concentration-dependent decrease in the mitochondrial membrane potential of the cells, evaluated by the ratio JC-1 aggregates over JC-1 monomer (ratio λex 544 λem 590 over λex 485 λem 538) [1].
In vivo	Opicapone inhibited rat peripheral COMT with ED50 values below 1.4 mg kg(-1) up to 6 h post-administration.?The effect was sustained over the first 8 h and by 24 h COMT had not returned to control values.?A single administration of opicapone resulted in increased and sustained plasma levodopa levels with a concomitant reduction in 3-O-methyldopa from 2 h up to 24 h post-administration, while tolcapone produced significant effects only at 2 h post-administration.?The effects of opicapone on brain catecholamines after levodopa administration were sustained up to 24 h post-administration.?Opicapone was also the least potent compound in decreasing both the mitochondrial membrane potential and the ATP content in human primary hepatocytes after a 24 h incubation period[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 100 mg/mL (242.03 mM), Sonication is recommended.
Keywords	Inhibitor \| inhibit \| COMT \| Opicapone
Inhibitors Related	Serotonin hydrochloride \| Risedronate Sodium \| Risedronic Acid \| 3-Methoxybenzamide \| Entacapone \| Minodronic acid monohydrate \| OU749 \| Ibandronate sodium \| Testosterone propionate \| Alendronate sodium hydrate \| Flopropione \| (E)-Daporinad
Related Compound Libraries	FDA-Approved & Pharmacopeia Drug Library \| Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| EMA Approved Drug Library \| Drug Repurposing Compound Library \| Inhibitor Library \| FDA-Approved Drug Library \| Metabolism Compound Library \| Clinical Compound Library \| Bioactive Compounds Library Max

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