| Name | Oleic acid |
| Description | Oleic acid (Glycon Wo) is a natural product, a common monounsaturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator. |
| In vitro | METHODS: Human tumor cells HCG-27, AGS, MDA-MB-231, SGC7901, BGC823 and MCF-7 were treated with Oleic acid (400 μM) for 24-72 h. Cell viability was detected using MTT.
RESULTS: Oleic acid stimulated cell viability in HGC-27, MDA-MB-231 cells, and inhibited cell viability in AGS, SGC7901, BGC823 and MCF-7 cells. [1]
METHODS: Renal cell carcinoma cells 786-O were treated with Oleic acid (0.05-0.2 mM/L) for 48 h. Apoptosis was detected by Flow Cytometry.
RESULTS: Oleic acid retarded apoptosis of 786-O cells in a concentration-dependent manner. [2] |
| In vivo | METHODS: To detect the antitumor activity in vivo, Oleic acid (10 mg/kg) was administered by gavage to LKB1fl/flp53fl/fl endometrial tumor mouse model five days per week for four weeks.
RESULTS: Oleic acid treatment for four weeks significantly inhibited tumor growth by 52.1%.Oleic acid exhibits anti-tumor activity in endometrial cancers, which is dependent on the PTEN/AKT/mTOR signaling pathway. [3]
METHODS: To study its role in ischemic injury, Oleic acid (10-30 mg/kg, 5% Tween 20 in sterile saline) was administered intraperitoneally to rodent models of middle cerebral artery occlusion (MCAO), photochromic and four-vessel occlusion (4-VO).
RESULTS: Oleic acid administration reduced MCAO-induced infarct volume and functional deficits, photochromic-induced infarct volume, and 4-VO-induced hippocampal neuronal death. [4] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (885.08 mM), Sonication is recommended.
5% DMSO+95% Saline : 3 mg/mL (10.62 mM), Solution.
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| Keywords | Sodium potassium pump | Oleic acid | Na+/K+ ATPase | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Apoptosis |
| Inhibitors Related | Sucrose | Stavudine | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Daidzein | Tributyrin | Ferulic Acid | Glycerol | Thymidine | Alginic acid | 3-Indoleacetic acid | Oxalic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Bitter Compound library | Cosmetic Ingredient Compound Library | Flavor Natural Product library | Human Endogenous Metabolite Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
