| Name | Ochromycinone |
| Description | Ochromycinone (STA 21) is a selective STAT3 inhibitor. |
| Cell Research | Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference) |
| In vitro | In cells, Ochromycinone inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. Ochromycinone remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, Ochromycinone also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2] |
| In vivo | In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 2 mg/mL (6.52 mM)
DMSO : 20 mg/mL (65.3 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | anticancer | Bacterial | dimerization | binding | STAT3 | Inhibitor | Ochromycinone | antimicrobial | STAT | inhibit | DNA | antibiotic |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
