Name | O-Nornuciferine |
Description | O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM. |
In vitro | In an in vitro screening of herbal materials for hERG blockers using an automated two-microelectrode voltage clamp assay on Xenopus oocytes, an alkaloid fraction of Nelumbo nucifera Gaertn. (lotus) leaves induced ???50% of hERG current inhibition at 100 μg/mL. Chromatographic separation resulted in the isolation and identification of (-)-asimilobine, 1, nuciferine, 2, O-Nornuciferine, 3, N-nornuciferine, 4, and liensinine, 5. In agreement with in silico predicted ligand-target interactions, 2, 3, and 4 revealed distinct in vitro hERG blockages measured in HEK293 cells with IC50 values of 2.89, 7.91, and 9.75 μM, respectively. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/mL (177.71 mM)
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Keywords | Inhibitor | Potassium Channel | O-Nornuciferine | KcsA | inhibit | ONornuciferine | O Nornuciferine |
Inhibitors Related | Minoxidil sulfate | Glibenclamide | (±)-Naringenin | Tetraethylammonium bromide | Halothane | Butamben | Neratinib | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Rare Natural Product Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |