Name | NSC59984 |
Description | NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. |
Cell Research | Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference) |
In vitro | NSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1] |
In vivo | In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : 49 mg/mL (184.7 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 55 mg/mL (207.34 mM), Sonication is recommended.
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Keywords | inhibit | Inhibitor | NSC-59984 | NSC59984 | MDM-2/p53 | NSC 59984 |
Inhibitors Related | MMRi64 | Rotenone | XI-006 | Pifithrin-μ | DPBQ | Roslin 2 bromide | BAY 1892005 | Indole-3-carbinol | Magnolol | RITA | P53R3 | CT-1 |
Related Compound Libraries | Anti-Lung Cancer Compound Library | Glycometabolism Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Ubiquitination Compound Library | Glutamine Metabolism Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |