| Name | Nrf2-ARE/hMAO-B/QR2 modulator 1 |
| Description | Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model. |
| In vitro | After incubating the ARE-blaHepG2 cell line with Nrf2-ARE/hMAO-B/QR2 modulator 1 for 16 hours, CCF4-AM substrate mixture was added, and fluorescence intensity was measured to assess the activity of the Nrf2-ARE pathway. The Results showed that at a concentration of 10μM, the expression of TuJ-1 and MAP-2 was highest, and the migration distance of mouse neural stem cells was also the greatest. The study indicates that Nrf2-ARE/hMAO-B/QR2 modulator 1 effectively activates the Nrf2-ARE pathway, inhibits hMAO-B and QR2, and demonstrates significant neuroprotective effects[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (195.11 mM), Sonication is recommended.
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| Inhibitors Related | Ethoxyquin | Kaolin | Aceglutamide | Allopurinol | Cysteamine hydrochloride | Metronidazole | 1,4-Naphthoquinone | Ethyl linoleate | L-Methionine | Paeonol | Methylene Blue trihydrate | Dimethyl phthalate |
| Related Compound Libraries | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Multi-Target Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
