| Name | Notoginsenoside R1 |
| Description | Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties. |
| In vitro | METHODS: Human colorectal cancer cells HCT-116 were treated with Notoginsenoside R1 (75-300 µM) for 48 h. Cell viability was measured by MTT assay.
RESULTS: Cell viability of HCT-116 cells treated with 75-300 µM Notoginsenoside R1 was not significantly different from that of the control. However, treatment with 500 µM Notoginsenoside R1 for 48 h resulted in a significant decrease in cell viability (58±7.26%) compared to control cells. [1]
METHODS: Human coronary artery smooth muscle cells hCASMC were treated with Notoginsenoside R1 (10 µM) for 24 h. The cells were stimulated with 10% FBS for 0-30 min, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Akt phosphorylation in hCASMCs was rapidly reduced in a time- and dose-dependent manner after Notoginsenoside R1 treatment, but no effect on ERK1/2 and JNK signaling was observed. notoginsenoside R1 caused a modest reduction in p38 MAPK phosphorylation, but this did not reach significance. [2] |
| In vivo | METHODS: To study the effect on neoplastic endothelial hyperplasia, Notoginsenoside R1 (10 mg/kg) was administered intraperitoneally to C57BL/6 J mice once daily for three weeks. A mouse femoral artery injury model was subsequently performed.
RESULTS: Notoginsenoside R1 attenuated neointimal formation after femoral artery injury in vivo.Notoginsenoside R1 treatment reduced neointimal formation by inhibiting VSMC proliferation. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 2.5 mg/mL (2.68 mM)
DMSO : 25 mg/mL (26.79 mM)
10% DMSO+90% Saline : 2.5 mg/mL (2.68 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| Keywords | Sanqi glucoside R-1 | I/R | Apoptosis | Inhibitor | anti-apoptosis,cardioprotection | saponin | inhibit | Notoginsenoside R 1 | neuroprotection | Abeta | Notoginsenoside R-1 | Sanqi glucoside R 1 | β-amyloid peptide | Notoginsenoside R1 | Sanchinoside R 1 | Sanchinoside R-1 | anti-inflammatory | Amyloid-β | anti-angiogenic | anti-oxidation |
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