| Name | N,N'-Dimethylthiourea |
| Description | N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] . |
| In vivo | N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1]. DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (479.98 mM), Sonication is recommended.
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| Keywords | N,N'-Dimethylthiourea | Inhibitor | N,N' Dimethylthiourea | inhibit | WIRS | scavengin | N,N'Dimethylthiourea | orally |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Antioxidant Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
