| Name | N,N'-Dimethylthiourea |
| Description | N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action [1][2] . |
| In vivo | N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1]. DMTU protects against WIRS-induced gastric mucosal lesions in rats by exerting its antioxidant action including ·OH scavenging and its anti-inflammatory action without affecting the stress response. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (479.98 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (19.2 mM), Sonication is recommended.
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| Keywords | WIRS | scavengin | orally | N,N'-Dimethylthiourea | N,N'Dimethylthiourea | N,N' Dimethylthiourea | Inhibitor | inhibit | Antioxidant |
| Inhibitors Related | Ethoxyquin | Cysteamine hydrochloride | Acetylcysteine | Imeglimin hydrochloride | L-Ascorbic acid | AFMK | Glucosamine | Gallic Acid Monohydrate | L-Cystine | Coenzyme Q10 | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Antioxidant Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
