| Name | NMN Nicotinamide mononucleotide powder 1094-61-7 |
| CAS | 1094-61-7 |
| EC Number: | 214-136-5 |
| Purity | >99% |
| Chemical name | beta-Nicotinamide mononucleotide,β-Nicotinamide mononucleotide,beta-NMN,nicotinamide ribonucleotide |
| Synonyms | β-NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate, β-Nicotinamide ribose monophosphate, NMN |
| Molecular Formula | C11H15N2O8P |
| Molecular Weight | 334.221 g/mol |
| InChI Key | DAYLJWODMCOQEW-TURQNECASA-N |
| Form | Crystalline or Lyophilized white powder |
| Appearance | white powder |
| Solubility | Soluble in water (100 g/l) |
| Application | Cosmetic,Supplement,IVD,Pharmaceutical |
| Testing Document | Available |
| Stability | Stable more than 6 months in room temperature |
| Bulk Density | 1.5-7g/ml |
| Particle size | >80 mesh |
| Storage Condition | Keep dry ,away from light, and store at 2℃- 8℃, long term store at -15℃ to -25℃ |
| Package | 10gram/bag ,50gram/bag , 1KG/bag, 25KG/drum |
| λmax | 210, 265 nm |
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| DESCRIPTION |
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| General description |
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| β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+. |
| Application |
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| β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. |
| Nicotinamide ribotide (NMN) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to NMN by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction NMN + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus NMN is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating NMN levels may play an important role in regulating cell function in physiological and pathophysiological conditions. |
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