| Name | Nitazoxanide |
| Description | Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction. |
| In vitro | In a model of abiotic piglet diarrhea, oral administration of Nitazoxanide (250 mg/kg/day) was effective in reducing the survival of parasites within the host organism. |
| In vivo | Nitazoxanide effectively inhibits the growth of a broad spectrum of protozoans and helminths, such as Blastocystis hominis, Entamoeba histolytica, and Trichomonas vaginalis, without exhibiting cytotoxicity. It demonstrates inhibitory concentrations against E. histolytica (IC50=0.017 mg/mL, IC90=0.776 mg/mL), G. intestinalis (IC50=0.004 mg/mL, IC90=0.067 mg/mL), and T. vaginalis (IC50= 0.034 mg/mL, IC90=2.046 mg/mL). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (162.72 mM)
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| Keywords | Parasite | parasitic | NSC-697855 | helminths | protozoa | NSC697855 | anthelmintic | Nitazoxanide | Giardia lamblia | NTZ | Influenza Virus | inhibit | enteric | Inhibitor | bacteria infecting | gastroenteritis ,virus | trophozoite | Autophagy | JEV |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Metronidazole | Doxycycline | Taurine | Curcumin | Paeonol | Naringin | Salicylic acid | Gefitinib |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
