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ChemicalBook Product Catalog Nilotinib hydrochloride

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Nilotinib hydrochloride NEW

$40.00 5mg

$57.00 10mg

$94.00 25mg

Min. Order
Purity100%
Cas No923288-95-3
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Nilotinib hydrochloride
CAS No	923288-95-3
EC-No
Min. Order
Purity	100%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Nilotinib hydrochloride
Description	Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myelogenous leukemia.
In vitro	Nilotinib hydrochloride (AMN107 hydrochloride) is a selective Abl inhibitor designed to interact with the ATP binding site of BCR-ABL with higher affinity than imatinib while being more potent than imatinib (IC50<30 nM ), also retains activity against most BCR-ABL point mutants that confer resistance to imatinib.[1] Nilotinib hydrochloride showed significant anti-tumor efficacy against GIST xenograft cell lines and imatinib-resistant GIST cell lines, among which the parental cell lines GK1C and GK3C showed imatinib sensitivity with IC50 of 4.59±0.97 μM and 11.15±1.48 μM, respectively.[2]
In vivo	Nilotinib hydrochloride (AMN107 hydrochloride) (40 mg/kg; oral gavage; daily; for 4 weeks; BALB/cSLc-nu/nu mice with GIST xenograft) demonstrated equivalent or superior antitumor effects in BALB/cSLc-nu/nu mice with GIST xenografts. Nilotinib hydrochloride Inhibited tumor growth by 69.6% in GK1X, 85.3% in GK2X, and 47.5% in GK3X xenograft line.[2] Nilotinib hydrochloride exerts significant healing effects on macroscopic and microscopic pathology scores in a rat model of indomethacin-induced enterocolitis and ensures considerable mucosal healing while reducing PDGFR alpha and beta levels and apoptosis in the colon Rating.[3]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 90 mg/ml (159.02 mM) Ethanol : 1 mg/ml (1.77 mM)
Keywords	Nilotinib Hydrochloride
Inhibitors Related	Stavudine \| Sodium 4-phenylbutyrate \| Hydroxychloroquine \| Guanidine hydrochloride \| Taurine \| Curcumin \| Oxyresveratrol \| Paeonol \| Naringin \| Gefitinib
Related Compound Libraries	FDA-Approved & Pharmacopeia Drug Library \| Bioactive Compound Library \| Approved Drug Library \| EMA Approved Drug Library \| Kinase Inhibitor Library \| Autophagy Compound Library \| Drug Repurposing Compound Library \| FDA-Approved Kinase Inhibitor Library \| Anti-Cancer Approved Drug Library \| Bioactive Compounds Library Max

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