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ChemicalBook Product Catalog API Vitamins and Minerals medicines Vitamin B drugs Nicotinic acid

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Nicotinic acid NEW

$0.20 1000KG

$6.00 1KG

Min. Order1KG
Purity99%
Cas No59-67-6
Supply Abilityg-kg-tons, free sample is available
Update time2024-03-29

Henan Fengda Chemical Co., Ltd

1YR

China

Since2023-02-10

AddressRoom 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Chemical Properties

Product Name	Nicotinic acid
CAS No	59-67-6
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/03/29

1. Materials information

Names

Name	Nicotinic acid
Synonym	More Synonyms

Nicotinic acid Biological Activity

Description	Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.Target: OthersNiacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition.Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61. [2]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun;164(6):1188-200. [3]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):209-15.

Chemical & Physical Properties

Density	1.473
Boiling Point	292.5±13.0 °C at 760 mmHg
Melting Point	234-238 ºC
Molecular Formula	C6H5NO2
Molecular Weight	123.11
Flash Point	130.7±19.8 °C
PSA	55.98000
LogP	0.15
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.571
Storage condition	0-6°C
Stability	Stable. Incompatible with strong oxidizing agents. May be light sensitive.
Water Solubility	1-5 g/100 mL at 17 ºC

MSDS

Nicotinic acid MSDS(Chinese)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT0525000

CHEMICAL NAME :
Nicotinic acid

CAS REGISTRY NUMBER :
59-67-6

BEILSTEIN REFERENCE NO. :
0109591

LAST UPDATED :
199710

DATA ITEMS CITED :
19

MOLECULAR FORMULA :
C6-H5-N-O2

MOLECULAR WEIGHT :
123.12

WISWESSER LINE NOTATION :
T6NJ CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
2571 mg/kg/90D-I

TOXIC EFFECTS :
Blood - change in clotting factors Blood - changes in platelet count

REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 152,861,1992

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
9713 mg/kg/58W-I

TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Skin and Appendages - sweating Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,496,1991

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
7 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,544,1982

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
730 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
5 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,544,1982

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
3500 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 38,241,1938

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
3720 mg/kg

TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,149,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
358 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
3500 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
5 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,831,1971

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Unreported

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
4 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041937

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
4550 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,741,1977

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
3500 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 38,241,1938 ** TUMORIGENIC DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
174 gm/kg/94W-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 38,106,1981 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81908 No. of Facilities: 1815 (estimated) No. of Industries: 10 No. of Occupations: 19 No. of Employees: 13494 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81908 No. of Facilities: 3028 (estimated) No. of Industries: 15 No. of Occupations: 46 No. of Employees: 61057 (estimated) No. of Female Employees: 26152 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	2810.0
WGK Germany	1
RTECS	QS3675000
Hazard Class	6.1
HS Code	29362990

Synthetic Route

Previous 1/75 Next

Nicotinyl alcoh...

100-55-0

~95%

Nicotinic acid

59-67-6

Literature: Mirza-Aghayan, Maryam; Molaee Tavana, Mahdieh; Boukherroub, Rabah Tetrahedron Letters, 2014 , vol. 55, # 2 p. 342 - 345

3-Mepy

108-99-6

~99%

Nicotinic acid

59-67-6

Literature: Jubilant Life Sciences Limited Patent: EP2428505 A2, 2012 ; Location in patent: Page/Page column 6-7 ;

Nicotinic acid ...

2398-81-4

~85%

Nicotinic acid

59-67-6

Literature: Ryzhakov, A. V.; Elaev, N. R. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 8 p. 859 - 861 Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 8 p. 1075 - 1076

Precursor & DownStream

Precursor 9	Previous 1/3 Next
CAS#:100-55-0 Nicotinyl alcohol CAS#:108-99-6 3-Mepy CAS#:2398-81-4 Nicotinic acid ... CAS#:500-22-1 Nicotinaldehyde
DownStream 10	Previous 1/3 Next
CAS#:10354-56-0 3-Pyridinecarbo... CAS#:109822-09-5 3-(3-carbamoylp... CAS#:5006-66-6 6-Hydroxynicoti... CAS#:609-71-2 2-Hydroxy acid

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

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Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.