| 名称 | NDMC101 |
| 描述 | NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. |
| 细胞实验 | Differentiation into osteoclast-like cells was examined by tartrate-resistant acid phosphatase (TRAP) staining and expression of osteoclast differentiation markers[1]. |
| 动物实验 | Collagen-induced arthritis (CIA) mice were administered test articles by gavages to assess its efficacy.?Then clinical, histological, and biochemical parameters were assessed to determine the effects of N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide (NDMC101) on synovial inflammation and bone erosion by hematoxlin and eosin staining and Enzyme-linked immunosorbent assay (ELISA)[1]. |
| 体外活性 | NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs).?Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1]. |
| 体内活性 | In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion.?Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 11 mg/mL (41.4 mM)
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| 关键字 | rheumatoid arthritis | inhibit | RAW 264.7 | NDMC-101 | NSAID | NDMC 101 | Bone | Inhibitor | Nuclear factor-κB | NF-κB | DPP | bone destruction | osteoblast | marrow-derived macrophages | NDMC101 | synovial inflammation | Nuclear factor-kappaB | Dipeptidyl Peptidase |
| 相关产品 | Lidocaine | Sitagliptin | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Vildagliptin | 4'-Hydroxychalcone | Sodium salicylate |
| 相关库 | 抗肺癌化合物库 | 抗胰腺癌化合物库 | 经典已知活性库 | HIF-1化合物库 | 细胞焦亡化合物库 | 抑制剂库 | 抗衰老化合物库 | 已知活性化合物库 | 抗癌化合物库 | 氧化还原化合物库 |
United States
