| Name | NBDHEX |
| Description | NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1). |
| In vitro | NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1;?LC(50) of 4.5 +/- 0.9 micromol/L).?Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump [1]. |
| In vivo | NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (33.63 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 145 mg/mL (487.67 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (33.63 mM), Solution.
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| Keywords | p38MAPK | NBDHEX | JNK | Inhibitor | inhibit | GSTP1-1 | GSSG | GlutathionePeroxidase | Glutathione Peroxidase | extrusion | cytotoxic | c-Jun | catalytic | Autophagy | Apoptosis | anticancer |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Autophagy Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | PPI Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
