N-Acetyl Selank Amidate is a synthetic, acetylated, C-terminal amidated hexapeptide research compound derived from the tetrapeptide tuftsin, featuring the sequence Ac‑Thr‑Lys‑Pro‑Arg‑Pro‑Gly‑Pro‑NH2 (Ac‑TKPRPGP‑NH2). It is supplied as the acetate salt in ready‑to‑use aliquots and is intended strictly for laboratory research. Typical molar mass is 792.94 g/mol; the compound is also known by the synonym Selank Etomidate. Suppliers commonly report a CAS number Not Assigned for this amidated form36.
Key Research Findings
Preclinical rodent studies have demonstrated a range of central nervous system and immunomodulatory effects. In hippocampal CA1 neurons, Selank (acetate) at 1 μM increased the amplitude and discharge rate of inhibitory postsynaptic currents. In behavioral models, it reduced affective responses and erroneous escape attempts in acutely stressed rats, increased orienting‑investigative behavior in unfamiliar environments, shortened immobility time in the forced swim test, and in a high‑anxiety Balb/c mouse strain increased open‑field locomotor activity (no effect in C57Bl/6). It also reduced apomorphine‑induced verticalization at 0.01 mg/kg and, at 100 μg/kg, decreased spleen expression of inflammation‑related genes Il2rg and Xcr1 after 90 minutes amidated analog N‑Acetyl Selank Amidate is reported to interact with GABA receptors and modulate IL‑6 expression in experimental contexts36.Intended Use and Safety
This material is sold for laboratory research use only. It is not for human consumption and must not be used for medical, veterinary, or household purposes. Standard laboratory safety practices should be followed, including the use of appropriate personal protective equipment (PPE), working in a controlled environment, and proper disposal in accordance with institutional and local regulations6.
China
