| Name | N-tert-butyl-α-Phenylnitrone |
| Description | N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier. |
| In vitro | Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation[1]. |
| In vivo | In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (282.10 mM)
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| Keywords | neuroprotective | adducts | COX | inhibit | Cyclooxygenase | ERK | ROS | Inhibitor | Scavenger | N-tert-butyl-α-Phenylnitrone | spin | BBB | N tert butyl α Phenylnitrone | N-benzylidene-2-Methylpropan-2-aMine Oxide | iNOS | N-tert-butyl-alpha-Phenylnitrone | nitroxide | antioxidant | N-tert-butyl-a-Phenylnitrone | Reactive Oxygen Species | MAPK | NtertbutylαPhenylnitrone |
| Inhibitors Related | Acetylcysteine | Acetaminophen |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max |
United States
