Name | MYCi361 |
Description | MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM). |
Animal Research | FVB or NSG male mice of 6-8 weeks of age and 25 g bearing established MycCaP tumors.MYCi361 treatment i.p. initially at 50 mg/kg twice daily for 2 days, then 70 mg/kg/day for 9 days |
In vitro | MYCi361 is a small-molecule MYC inhibitors that inhibits the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 values[1]. |
In vivo | MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (168.1 mM), Sonication is recommended.
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Keywords | c-Myc | MYCi 361 | NUCC0196361 | MYCi361 | NUCC 0196361 | MYCi-361 | inhibit | Inhibitor | Myc |
Inhibitors Related | BTYNB | MYCMI-6 | VPC-70063 | KJ Pyr 9 | EN4 | Mycro 3 | 10058-F4 | 10074-A4 | ML327 | MYCi975 | 10074-G5 | Nicotinamide N-oxide |
Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library |