| Name | MPP+ iodide |
| Description | MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells. |
| In vitro | METHODS: Human neuroblastoma cells SH-SY5Y were treated with MPP+ iodide (1-4 mM) for 12-48 h, and cell viability was detected using CCK-8 Assay. |
| In vivo | METHODS: To test for acute toxicity to embryonic or neonatal mice, MPP+ iodide (8.6-34.2 mg/kg) was injected intraperitoneally into pregnant or neonatal mice.
RESULTS: Neurotoxicity induced by a single injection of MPP+ iodide was transient and recoverable in embryonic and neonatal mice. In contrast, no significant changes in MAO-A and MAO-B expression levels were observed in MPP+ iodide-treated mice. [3] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (336.54 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (13.46 mM), Sonication is recommended.
DMSO : 135 mg/mL (454.35 mM), Sonication is recommended.
|
| Keywords | respiratory | neurotoxic | neurons | MPP+ iodide | MPP+ Iodide | MPP+ | MitochondrialMetabolism | Mitochondrial Metabolism | Inhibitor | inhibit | dopaminergic | complex | chain | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Valproic Acid | Curcumin | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Cuproptosis Compound Library | Glycometabolism Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Autophagy Compound Library | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
