Name | Moslosooflavone |
Description | Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activity of NF-kappaB in LPS/IFN-gamma stimulated RAW 264.7 macrophages. |
Animal Research | The chemical constituents, isolated and purified by column chromatography from Saussurea invo lucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice[2]. |
In vitro | 5-hydroxy-7,8-dimethoxyflavone significantly decreased TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and nitric oxide (NO) secretions from LPS/IFN-gamma stimulated RAW 264.7 cells[1]. |
In vivo | 5-hydroxy-7,8-dimethoxyflavone can significantly prolong the survival time of hypoxic mice[2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 10 mg/mL (33.52 mM)
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Keywords | Inhibitor | anti-hypoxia | flavonoid | anti-inflammatory | Moslosooflavone | inhibit | Reactive Oxygen Species |
Inhibitors Related | Sodium Thiocyanate | Imeglimin hydrochloride | L-Ascorbic acid | α-Vitamin E | Diethylmaleate | Glucosamine | D-(+)-Glucono-1,5-lactone | Lidocaine hydrochloride | Lycopene | Naringenin | Indole-3-carbinol | Diallyl disulfide |
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