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ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Antiseptics & Disinfectants Drugs Morphothiadin

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Morphothiadin NEW

$97.00 1mg

$297.00 5mg

$474.00 10mg

Min. Order
Purity99.88%
Cas No1092970-12-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Morphothiadin
CAS No	1092970-12-1
EC-No
Min. Order
Purity	99.88%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Morphothiadin
Description	Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV (IC50 of 12 nM).
In vitro	Morphothiadin is a potent inhibitor of both wild-type and adefovir-resistant HBV (IC50 of 12 nM) and shows no toxicity up to 25 μM. The CC50 for primary hepatocytes is 115 μM (P<0.001), while the CC90 in HepAD38 cells is 190 μM (P<0.01). Morphothiadin strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02)[2].
In vivo	Virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 100 mg/mL (196.31 mM), Sonication is recommended. H2O : insoluble
Keywords	GLS 4 \| inhibit \| HBV \| Inhibitor \| GLS-4 \| Hepatitis B virus \| Morphothiadin
Inhibitors Related	Doxorubicin hydrochloride \| Osthole \| RO8191 \| Tenofovir Disoproxil Fumarate \| Thiamine hydrochloride \| 4,5-Dicaffeoylquinic acid \| 4-Hydroxyacetophenone \| Telbivudine \| Tenofovir \| Bifendate
Related Compound Libraries	Bioactive Compound Library \| ReFRAME Related Library \| Drug Repurposing Compound Library \| Anti-Viral Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Clinical Compound Library \| Bioactive Compounds Library Max \| Anti-Infection Compound Library

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