| Name | Mometasone furoate |
| Description | Mometasone furoate (Sch32088) is a pregnadienediol derivative with anti-allergic and anti-inflammatory properties, used in the management of asthma and allergic rhinitis, as well as a topical treatment for skin disorders. |
| In vitro | Both 0.02% Mometasone furoate and 0.1% Fluticasone propionate significantly suppress the increase in antigen-induced nasal rubbing even six hours after topical application, demonstrating their lasting effects. Mometasone furoate reduces nasal rubbing in rats and, at the highest tested dose in mice (3mg/kg), inhibits the increased sensitivity to aerosolized acetylcholine. The compound dose-dependently suppresses the elevation of eosinophil counts in the bronchoalveolar lavage fluid and lung tissue of mice challenged with sensitizing ovalbumin. Furthermore, a dosage of 33 mg/kg Mometasone furoate lowers the percentage of CD44+ T helper cells (activated/memory cells) to levels observed in mice not challenged with sensitizing ovalbumin, indicating its immunomodulatory potential. |
| In vivo | Mometasone furoate effectively inhibits the production of cytokines, including interleukin (IL)-4, IL-5, and interferon-γ, in human CD4+ T cells stimulated by anti-CD3. It also efficiently suppresses the activation of Th cells, including type 2 helper T (Th2) cells, in draining lymph nodes, leading to the suppression of the IgE response. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (86.3 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | steroid | skin corticosteroid | Sch-32088 | Sch 32088 | Mometasone Furoate | Mometasone furoate | Inhibitor | inhibit | hay fever | GlucocorticoidReceptor | Glucocorticoid Receptor | eczema | asthma | Anti-inflammatory |
| Inhibitors Related | Nimodipine | Hydrocortisone | Mifepristone | Prednisone | Prednisolone acetate | Cortisone | Dexamethasone acetate | Dexamethasone | Dexamethasone Phosphate disodium | Prednisone acetate | Desonide | Corticosterone |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Approved Drug Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
