| Name | ML216 |
| Description | ML216 (CID-49852229) is a small molecule inhibitor of BLM helicase with an IC50 of 1.8 μM, demonstrating 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM). |
| Cell Research | Cells were treated with BLM inhibitors at the indicated concentrations for up to 72 hr. At each time point, the WST-1 reagent (a pale tetrazolium derivative converted to an intensely-colored formazan product by the action of mitochondrial dehydrogenases) was added, and after a 4 hr incubation the plates were analyzed optically at 450 nm with a reference wavelength of 690 nm [2]. |
| In vitro | ML216 shows cell-based activity and can induce sister chromatid exchanges, enhance the toxicity of aphidicolin, and exert antiproliferative activity in cells expressing BLM, but not those lacking BLM [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (13.04 mM), Sonication and heating are recommended.
|
| Keywords | WRN | unwinding | toxicity | sister | RNASynthesis | RNA Synthesis | ML-216 | ML216 | ML 216 | Inhibitor | inhibit | helicase | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | DNA | CID49852229 | CID 49852229 | chromatid | BLM helicase | BLM | anti-proliferative | Anticancer |
| Inhibitors Related | 5-Fluorouracil | Adenine hemisulfate | Rifaximin | Guanidine hydrochloride | Hexane-1,6-diol | Methotrexate disodium | 1,4-Naphthoquinone | Adenine | Carbazole | Thymidine | Docosanoic acid | Usnic Acid |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Covalent Inhibitor Library | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
