| Name | ML-SA1 |
| Description | ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1]. |
| In vitro | ML-SA1 (25 μM; 0~14 hours; A549 cells) potentially affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows no cytotoxicity at concentrations up to 200 μM. It significantly suppresses DENV2 RNA levels with an IC50 of 8.93 μM[1]. ML-SA1 also reduces ZIKV RNA and protein levels in a dose-dependent manner, with an IC50 of 52.99 μM against ZIKV RNA. As an activator of TRPMLs, ML-SA1 is a potent inhibitor of DENV2 and ZIKV in vitro, promoting lysosomal acidification and protease activity to inhibit viral infection, and can induce autophagy in Huh7 or A549 cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 17 mg/mL (46.91 mM), Sonication is recommended.
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| Keywords | Zika | virus | TRPVChannel | TRPV Channel | TRPML | TRPChannel | TRP Channel | Transient receptor potential channels | selective | protease | ML-SA-1 | ML-SA1 | MLSA1 | ML SA1 | lysosomal | Inhibitor | inhibit | Dengue | broad-spectrum | autophagy | antiviral | acidification |
| Inhibitors Related | Rosiglitazone | Caffeic Acid | Camphor | Pyrolin | Probenecid | Penicillin G potassium | 3,4,5-Trimethoxybenzaldehyde | Sorbic acid | 1,4-Cineole | (E)-3-(p-Tolyl)acrylaldehyde | trans-Cinnamaldehyde | Naringenin |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Infection Compound Library |
United States
