| Name | Mizoribine |
| Description | Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
| In vitro | Mizoribine selectively inhibits guanine ribonucleotide synthesis in purified T-cells, while the mechanism of 6-thioguanine (6MP) appears to rely more on the depletion of adenine ribonucleotides. In a dose-dependent manner, Mizoribine at 1-50 mg/mL suppresses T-cell proliferation induced by all tested stimuli by 10-100%. This suppression is reversible with the addition of guanosine to replenish the guanine nucleotide pool when 50 mM is incorporated. Furthermore, Mizoribine impedes HCV RNA replication with an IC50 of 100 μM and causes a reduction in intracellular GTP levels, with GTP supplementation reversing its antiproliferative effect. |
| In vivo | Administration of 5 or 10 mg/kg Mizoribine resulted in increased expression of MCP-1, OPN, and TGF-β1 mRNA in untreated OLETF rats. Simultaneously, this dose of Mizoribine inhibited urinary albumin excretion and attenuated the progression of glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in the rat kidneys. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (231.46 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 47 mg/mL (181.3 mM)
|
| Keywords | Immunosuppressant | SARS-CoV | Mizoribine | IMPDH | NSC289637 | nucleoside | Hepatitis C virus | HE-69 | HCV | SARS coronavirus | NSC-289637 | Inhibitor | inhibit | HE69 |
| Inhibitors Related | Kojic acid | Methyl 2-amino-5-bromobenzoate | Remdesivir | Ribavirin | Silymarin | Hydroxychloroquine | Chloroquine phosphate | Oxyresveratrol | Artemisinin | 2-Ketoglutaric acid | Dexamethasone | Methyl cinnamate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Natural Product Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
United States
