| Name | Mitraphylline |
| Description | Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils. |
| In vitro | The alkaloids of Uncaria tomentosa micropropagated plantlets and root cultures were isolated and identified by NMR and mass spectrometry. Plantlets yielded pteropodine (1), isopteropodine (2), Mitraphylline (3), isoMitraphylline (4), uncarine F (5), speciophylline (6), rhynchophylline (7) and isorhynchophylline (8). In plantlets growing under continuous light, tetracyclic alkaloids 7 and 8 decreased from 20 ± 1.8 at 2 months to 2.2 ± 0.33 mg/g dry wt at 6 months, while the pentacyclic alkaloids 1-4 increased from 7.7 ± 1.4 to 15 ± 0.05 mg/g dry wt, supporting their biogenetic conversion. Micropropagated plantlets produced four times more alkaloids (27.6 ± 3.1 mg/g dry wt) than greenhouse plants. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 6.76 mg/mL (18.35 mM), Sonication is recommended.
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| Keywords | Uncaria | tomentosa | TNF-α | NF-κB | NFκB | NF-kB | NFkB | Mitraphylline | Inhibitor | inhibit | ILReceptor | IL Receptor |
| Inhibitors Related | Naringin dihydrochalcone | Methylamine HCl | Diethylmaleate | Glucosamine | L-Arginine | Lidocaine hydrochloride | Apremilast | N,N-Dimethylacetamide | Dexamethasone | Indole-3-carbinol | Lenalidomide | Diallyl disulfide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
