| 名称 | Mitoxantrone dihydrochloride |
| 描述 | Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
| 细胞实验 | The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3]. |
| 体外活性 | In a murine air pouch model of inflammation, methotrexate demonstrated an inhibitory concentration 50 (IC50) of 0.08 mg/kg per week. |
| 体内活性 | Methotrexate inhibits the de novo synthesis of purines and pyrimidines, the formation of polyamines, and the transmethylation reactions of DNA, RNA, phospholipids, and proteins. It suppresses the enzyme thymidylate synthase, leading to a deficiency of thymidylate inside cells, which ultimately results in antiproliferative cytotoxicity. Methotrexate enters cells either through active transport or facilitated diffusion and, once inside, polyglutamation inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 38.8 mg/mL (75 mM)
H2O : 2.6 mg/mL (5 mM)
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| 关键字 | B-CLL cells | NSC 301739 | MCF-7 | Endogenous Metabolite | Orthopoxvirus | Inhibitor | Mitoxantrone dihydrochloride | breast cancer | Apoptosis | lymphocytes | leukaemia | mitozantrone | Topoisomerase | Protein kinase C | mitozantrone Dihydrochloride | NSC301739 | inhibit | Mitoxantrone Dihydrochloride | PKC | antitumor | Mitoxantrone | Mitozantrone | HL60 cells | Mitoxantrone Hydrochloride |
| 相关产品 | Berberine chloride | EIDD-1931 | Flumequine | Norfloxacin | α-Vitamin E | Prulifloxacin | Enoxacin | Ciprofloxacin | Ciprofloxacin monohydrochloride | Etoposide |
| 相关库 | 神经退行性疾病化合物库 | 激酶抑制剂库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 抗病毒库 | 抑制剂库 | FDA 上市激酶抑制剂库 | 抗癌上市药物库 | FDA 上市药物库 | 抗癌活性化合物库 |
United States
