| Name | Mitiperstat |
| Description | Mitiperstat (AZD-4831) is an irreversible, highly selective, oral myeloperoxidase (MPO) inhibitor. Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC50 values of 1.5 nM and 0.69 μM, respectively. Mitiperstat exhibits weak inhibition of CYP3A4 with an IC50 of 6 μM. Mitiperstat is suitable for research into diseases such as chronic obstructive pulmonary disease, heart failure with preserved ejection fraction, and non-alcoholic steatohepatitis. |
| In vivo | Methods: BALB/c mice were intraperitoneally injected with yeast polysaccharides to induce neutrophilic peritonitis. Mitiperstat (0.01, 0.1, 1.0, 10 μmol/kg) was administered orally 2 hours prior to modeling. Mice were euthanized 2 hours after yeast polysaccharide injection.
Results: Mitiperstat exhibited dose-dependent inhibition of peritoneal MPO activity. The lowest effective dose was 0.1 μmol/kg (total plasma concentration 1.7 nM at 4 hours post-administration). [1]
Methods: Beagle dogs and SD rats received Mitiperstat at 100 mg/kg/day (9 months) and 125 mg/kg/day (6 months), respectively. Body weight, food intake, and pathology were monitored to determine the No Observed Adverse Effect Level (NOAEL).
Results: No abnormalities in body weight, food intake, or pathology were observed in Beagle dogs or SD rats at the maximum dose. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.99 mM), Sonication is recommended.
DMSO : 135 mg/mL (403.2 mM), Sonication is recommended.
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| Keywords | MPO | Mitiperstat | GlutathionePeroxidase | Glutathione Peroxidase | AZD-4831 | AZD 4831 |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | 4-Aminosalicylic acid | Naringin | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Glutamine Metabolism Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
United States
