| Name | Mevastatin |
| Description | Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. |
| In vitro | Mevastatin competitively inhibits HMG-CoA reductase, subsequently reducing cholesterol synthesis in the liver. After 14 days of high-dose treatment, a more than 30% increase in baseline absolute cerebral blood flow was observed. Oral administration of Mevastatin at doses of 5 mg/kg and 20 mg/kg led to reductions in serum cholesterol levels 3 hours post-administration, with the 20 mg/kg dosage decreasing serum cholesterol by approximately 30%. |
| In vivo | The bicyclic portion of Mevastatin binds to the active site of coenzyme A. Mevastatin elevates eNOS mRNA and protein levels, reduces infarct size, and ameliorates neurological deficits in a dose- and time-dependent manner. At a concentration of 0.01 pg/mL (26 nM), Mevastatin can reduce cholesterol synthesis by 50% compared with the control group. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (128.04 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Statins | RANKL | phosphorylation | NF-κB | neuroprotection | Mevastatin | lipid-lowering | Inhibitor | inhibit | HMGCR | HMGCoAReductase | HMG-CoA Reductase (HMGCR) | HMG-CoA reductase | HMGCoA Reductase | eNOS | EGFR | CES1 | cardiovascular | BMP-2 | Bacterial | Autophagy | Apoptosis | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Cysteamine hydrochloride | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Doxycycline | Tributyrin | Paeonol | Naringin | Dimethyl sulfoxide | Alginic acid |
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United States
