Methylene Blue trihydrate was first synthesized with zinc chloride salt in 1876, and has since been mainly used for:
(1) methemoglobinemia: low concentration methylene blue is used to treat methemoglobinemia caused by nitrite, chlorate, quinone, quinone imide, aniline and nitrobenzene;
(2) cyanide poisoning: high concentrations of methylene blue can be used for cyanide poisoning;
(3) Combined with local anesthetics for local analgesia;
(4) In recent years, clinical trials have also been used to treat infectious and traumatic shock, cancer, herpes zoster, etc. Pharmacological studies have shown that methylene blue has detoxification, analgesia, antibacterial, antiviral and anti-tumor effects, and can correct the hemodynamic disorder of septic shock patients and treat abnormal penile erection.
Methylene Blue trihydrate is widely used in chemical indicators, dyes, biological dyes and drugs. Especially in the dyeing industry, used to manufacture ink, etc., the amount is large, in the following areas, methylene blue is also widely used.
1 Industrial field: methylene blue is a dye compound. Industrial grade methylene blue is often used for dyeing cotton, silk, paper, etc., and can also be used in the coloring of bamboo and wood and the manufacture of ink and color lake. In addition, it is often used as a bacterial stain, indicator, etc.
2 Medical field: methylene blue has been used in the medical field for a long time. Due to the REDOX properties of methylene blue, it can be used to relieve cyanide, nitrite, aniline, acetanilide poisoning, or methemoglobin disease caused by sulfonamides and other drugs. In recent years, researchers have also studied the application of methylene blue and its metabolites in various bacterial and viral infections, cancers and central nervous system diseases such as depression, schizophrenia, Alzheimer's disease, etc.
3. Aquaculture: methylene blue can be used as a disinfectant in aquaculture. The principle is that the ionic compounds formed by methylene blue in aqueous solution can compete with the microbial enzyme system for hydrogen ions and inactivate the enzyme, resulting in the loss of microbial survival. It can also be used as an antifungal drug to reduce the death rate in fish transportation, such as small melon worm disease, loxosiphon disease, red mouth disease, water mildew disease and juvenile sticky disease of litopenaeus vannamei.
4 Skin care field: Studies have shown that methylene blue also has certain potential in skin care. Methylene blue can remove free radicals, stimulate cell proliferation in young and old dermal fibroblasts, and thus improve skin vitality, promote skin elasticity and collagen synthesis, and protect skin matrix through the degradation of matrix metalloproteinases. Therefore, methylene blue can be a promising agent in anti-aging cosmetics.
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