Common Name | (Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13) |
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CAS Number | 158563-45-2 | Molecular Weight | 1206.504 |
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Density | 1.4±0.1 g/cm3 | Boiling Point | N/A |
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Molecular Formula | C61H87N15O9S | Melting Point | N/A |
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MSDS | N/A | Flash Point | N/A |
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Use of (Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].
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