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ChemicalBook Product Catalog API Mertansine

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Mertansine NEW

$30.00 1mg

$64.00 5mg

$98.00 10mg

Min. Order
Purity99.76%
Cas No139504-50-0
Supply Ability10g
Update time2024-11-08

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Mertansine
CAS No	139504-50-0
EC-No
Min. Order
Purity	99.76%
Supply Ability	10g
Release date	2024/11/08

Product Introduction

Bioactivity

名称	Mertansine
描述	Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.
体外活性	METHODS: HCT-15 and A431 cells were incubated with Mertansine (0-3 nM) for 72 hours, then the medium was removed from the plate and replaced with fresh medium. Allow the culture to grow and form colonies for 7-10 days after plating. Cultures were fixed, stained with 0.2% crystal violet in 10% formalin/PBS, and colonies were counted. RESULTS Mertansine can inhibit the growth of HCT-15 and A431 cells. [1] METHODS: 4T1 cells were incubated with Mertansine (5-100 μg/mL) for 4 hours, and cell viability was detected by CCk8. RESULTS Mertansine can inhibit the growth of 4T1 cells.[2] METHODS: MDA-MB-231 cells were incubated with Mertansine (0.001355–13.55μM) for 48 hours, and cancer cell viability was detected by MTT. RESULTS Mertansine can effectively inhibit the proliferation of MDA-MB-231 cells, with an IC50 value of 0.12 μM. [3]
体内活性	METHODS: The anti-tumor activity of Mertansine (0.5 mg/kg) was evaluated in mice with orthotopic 4T1 tumors. RESULTS Cancer cell apoptosis was significantly increased, and the effect was dose-dependent. [2] METHODS: The in vivo therapeutic properties of Mertansine were evaluated using MDA-MB-231 triple-negative breast tumor mice. Mertansine was administered every 3 days for a total of four injections at a dose of 0.8 mg/kg. RESULTS Mertansine demonstrated modest inhibition of cancer cell growth in MDA-MB-231 triple-negative mammary tumor mice.[3]
存储条件	store at low temperature \| Powder: -20°C for 3 years \| Shipping with blue ice.
溶解度	DMSO : 83.33 mg/mL (112.87 mM), The compound is unstable in solution, please use soon. H2O : < 0.1 mg/mL (insoluble)
关键字	Maytansinoid DM-1 \| Maytansinoid DM 1 \| melanoma \| Inhibitor \| B16F10 \| ADC Payload \| ADC Cytotoxin \| DM-1 \| DM 1 \| tubulin \| Microtubule/Tubulin \| antiproliferative \| inhibit \| mitosis \| Mertansine \| antitumor \| ADC
相关产品	Dexamethasone acetate \| Methylene Blue trihydrate

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